CORDYCEPS (CORDYCEPS MILITARIS)
Improves respiratory health
Increases oxygen uptake
Boost heart health
Detoxifies the body
Prevents certain types of cancer
Slows the aging process
Improves the Immune system
Supports a healthy libido*
Promotes healthy kidney function*
Supports athletic performance
Cordyceps militaris belongs to the phylum Ascomycota classified in the order hypocreales, as spores are produced internally inside a sac, called ascus. It is an entomopathogenic fungus having an annual appearance which often grows parasitically on lepidopteron larvae and pupae of insects and spiders. It normally inhabits on the surface of insects pupae in winters and leading to the formation of fruiting body in summers justifying its name as “winter-worm summer-grass”. an excellent source of bioactive metabolites with more than 21 clinically approved benefits on human health including anti-diabetic, anti-tumor, anti-oxidative, immunomodulatory, sexual potentiator and anti-ageing effects. Cordycepin alone has been widely explored for its anti-cancer/anti-oxidant activities, thus, holding a strong pharmacological and therapeutic potential to cure many dreadful diseases in the future.
The adrenals are intimately connected with the production and metabolism of thyroid hormones thyroxine (T4) and triiodothyronine (T3). Studies have demonstrated that the cordyceps mushroom improves adrenal function, which supports the optimization of these thyroid hormone levels. Cordyceps has also been shown to help us utilize oxygen more efficiently, boosting cellular energy – in the form of ATP (adenosine tri-phosphate) – and combating adrenal fatigue. Numerous studies have demonstrated the regulatory function of cordyceps sinenesis on heart rhythm irregularities like cardiac arrhythmias and chronic heart failure.
One study also tested the effects of a Cordyceps-containing mushroom blend on exercise performance in younger adults. After three weeks, participants’ VO2 max had increased by 11%, compared to a placebo.
In one study, researchers tested their effects on exercise capacity in 30 healthy older adults using a stationary bike. Participants received either 3 grams per day of a synthetic strain of Cordyceps called CS-4 or a placebo pill for six weeks. By the end of the study, VO2 max had increased by 7% in participants who had taken CS-4, while participants given the placebo pill showed no change.
Several studies have found that Cordyceps increase antioxidants in aged mice, helping improve memory and sexual function. Antioxidants are molecules that fight cell damage by neutralizing free radicals, which can otherwise contribute to disease and aging. One study found that mice that given Cordyceps lived several months longer than mice given a placebo.
Researchers believe the fungi may exert anti-tumor effects in several ways.
In test-tube studies, Cordyceps have been shown to inhibit the growth of many types of human cancer cells, including lung, colon, skin and liver cancers. Studies in mice have also shown that Cordyceps have anti-tumor effects on lymphoma, melanoma and lung cancer. Research has shown that when human cells are exposed to Cordyceps, special proteins that increase inflammation in the body become suppressed. Thanks to these potential effects, researchers believe Cordyceps may serve as a useful anti-inflammatory supplement or drug. Cordyceps may also have topical uses. One study found it reduced skin inflammation when applied topically in mice, further demonstrating its anti-inflammatory properties.
Das SK, Masuda M, Sakurai A, Sakakibara M. Medicinal uses of the mushroom Cordyceps militaris: current state and prospects. Fitoterapia. 2010;81:961–968.
Won SY1, Park EH. Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. https://www.ncbi.nlm.nih.gov/pubmed/15619578
Kim KM1 Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppressing NF-kappaB activation. 2003 Jul 1;190(1):1-8. https://www.ncbi.nlm.nih.gov/pubmed/12831777
Seong-Yeol Park Anti-inflammatory effects of Cordyceps mycelium (Paecilomyces hepiali, CBG-CS-2) in Raw264.7 murine macrophages2014 Dec 5. doi: 10.1007/s13596-014-0173-3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371127/
Katie R. Hirsch Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementationJul 13. doi: 10.1080/19390211.2016.1203386 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236007/
Ji DB Antiaging effect of Cordyceps sinensis extract.2009 Jan;23(1):116-22. doi: 10.1002/ptr.2576.https://www.ncbi.nlm.nih.gov/pubmed/18803231
Li XT Protective effects on mitochondria and anti-aging activity of polysaccharides from cultivated fruiting bodies of Cordyceps militaris.https://www.ncbi.nlm.nih.gov/pubmed/21061463
Xiao JH Polysaccharides from the Medicinal Mushroom Cordyceps taii Show Antioxidant and Immunoenhancing Activities in a D-Galactose-Induced Aging Mouse Model. 2012;2012:273435. doi: 10.1155/2012/273435. Epub 2012 Mar 29. https://www.ncbi.nlm.nih.gov/pubmed/22536281
V. Lobo Free radicals, antioxidants and functional foods: Impact on human health 2010 Jul-Dec; 4(8): 118–126. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249911/
Nakamura K Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice.1999 Mar;79(3):335-41. https://www.ncbi.nlm.nih.gov/pubmed/10230862
Wu JY Inhibitory effects of ethyl acetate extract of Cordyceps sinensis mycelium on various cancer cells in culture and B16 melanoma in C57BL/6 mice.2007 Jan;14(1):43-9. Epub 2006 Jan 19. https://www.ncbi.nlm.nih.gov/pubmed/16423520
Ng TB Pharmacological actions of Cordyceps, a prized folk medicine. 2005 Dec;57(12):1509-19.https://www.ncbi.nlm.nih.gov/pubmed/16354395
Lee S Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells. 2015 Jul;53(7):468-74. doi: 10.1007/s12275-015-5198-x. Epub 2015 Jun 27.https://www.ncbi.nlm.nih.gov/pubmed/26115996
Lee HH Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis.2015 Jul 4;23:35. doi: 10.1186/s40199-015-0117-6. https://www.ncbi.nlm.nih.gov/pubmed/26141646
Lee HH Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis 2015 Jul 4;23:35. doi: 10.1186/s40199-015-0117-6.
He T, Zhao R, Lu Y, Li W, Hou X, Sun Y, Dong M, Chen L Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases. Evid Based Complement Alternat Med. 2016;2016:1360386. Epub 2016 Sep 18.
Tuli HS, Sandhu SS, Sharma AK. Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin. 3 Biotech. 2014;4(1):1–12. doi:10.1007/s13205-013-0121-9
Mei QB, Tao JY, Gao SB, et al. [Antiarrhythmic effects of cordyceps sinensis (Berk.) Sacc] [in Chinese]. Zhongguo Zhong Yao Za Zhi. 1989 Oct;14(10):616-18, 640. [PMID: 2597326]