LION'S MANE (HERICIUM AMERICANUM)

  • Improves cognitive function

  • Provides cerebral and nervous system support

  • Many studies have identified a NGF (Nerve Growth Factor) in Lion’s Mane

  • Enhanced memory

  • Repairs myelin-sheaths

  • Acts as a natural anti-depressant

  • Enhances immune system

  • Beneficial effects on digestion

  • Helps treat peptic ulcers

The subject of recent studies, Lion’s Mane is renowned for providing support to the brain and nervous system. In one study, lion’s mane dietary supplements appeared to give mice better object recognition and recognition memory. Other researchers have concluded that the mushrooms may have the potential to treat or prevent diseases that cause a decline in cognitive health, such as Parkinson’s disease and Alzheimer’s disease. An older Japanese study on adults aged between 50 and 80 years with mild cognitive impairment found that daily consumption of mushroom extract for 16 weeks led to higher scores on cognitive function scales compared with a placebo group. These scores decreased again once the participants stopped taking the extract.

 

Some research suggests that extracts of lion’s mane mushrooms may encourage nerve cells to grow and repair more quickly. One study showed that rats with nerve damage receiving a daily extract of lion’s mane mushrooms had quicker nerve regeneration than control animals. In vitro studies report that lion’s mane mushrooms can result in antibacterial activity that improves digestion. Research in mice supports these findings by showing that extracts of lion’s mane may protect against stomach ulcers. A 2015 study on rats, in which they ingested lion’s mane extract for 6 weeks, showed positive results, including lower blood sugar levels, reduced feelings of nerve pain, and improved antioxidant activity. The antioxidant properties of lion’s mane mushrooms may play a role in cancer prevention or treatment.

The results of an in vitro study indicate that lion’s mane extracts have therapeutic potential against human leukemia. A study using animal models found that these mushroom extracts may also fight liver, colon, and gastric cancer cells. Research on rats showed that the mushroom extracts might have a cholesterol-lowering effect and may boost the activity of the intestinal immune system. The results of another study on mice indicate that a protein in lion’s mane mushrooms encourages the growth of beneficial gut bacteria that strengthen immunity.

SOURCES:

Abdulla, M. A., Fard, A. A., Sabaratnam, V., Wong, K. H., Kuppusamy, U. R., Abdullah, N., & Ismail, S. (2011). Potential activity of aqueous extract of culinary-medicinal lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats [Abstract]. International Journal of Medicinal Mushrooms, 13(1), 33–39
https://www.ncbi.nlm.nih.gov/pubmed/22135902

Abdullah, N., Ismail, S. M., Aminudin, N., Shuib, A. S., & Lau, B. F. (2012). Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Evidence-Based Complementary and Alternative Medicine, 2012
https://www.hindawi.com/journals/ecam/2012/464238/

Brandalise, F., Cesaroni, V., Gregori, A., Repetti, M., Romano, C., Orrù, G., ... Rossi, P. (2017, January 1). Dietary supplementation of Hericium erinaceus increases mossy fiber-CA3 hippocampal neurotransmission and recognition memory in wild-type mice. Evidence-Based Complementary and Alternative Medicine, 2017
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237458/

Chiu, C.-H., Chyau, C.-C., Chen, C.-C., Lee, L.-Y., Chen, W.-P., Liu, J.-L., ... Mong, M.-C. (2018, February). Erinacine A-enriched Hericium erinaceus mycelium produces antidepressant-like effects through modulating BDNF/PI3K/Akt/GSK-3β signaling in mice. International Journal of Molecular Sciences, 19(2), 341
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855563/

Choi, W.-S., Kim, Y.-S., Park, B.-S., Kim, J.-E., & Lee, S.-E. (2013, June 30). Hypolipidaemic effect of Hericium erinaceum grown in Artemisia capillaris on obese rats. Mycobiology, 41(2), 94–99
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714447/

Diling, C., Chaoqun, Z., Jian, Y., Jian, L., Jiyan, S., Yizhen, X., & Guoxiao, L. (2017, June 12). Immunomodulatory activities of a fungal protein extracted from Hericium erinaceus through regulating the gut microbiota. Frontiers in Immunology, 8, 666
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492111/

Kim, S. P., Kang, M. Y., Choi, Y. H., Kim, J. H., Nam, S. H., & Friedman, M. (2011, June 8). Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells [Abstract]. Food & Function, 2(6), 348–356
https://www.ncbi.nlm.nih.gov/pubmed/21779573

Lakshmanan, H., Raman, J., David, P., Wong, K. H., Naidu, M., & Sabaratnam, V. (2016, December 24). Haematological, biochemical and histopathological aspects of Hericium erinaceus ingestion in a rodent model: A sub-chronic toxicological assessment [Abstract]. Journal of Ethnopharmacology, 194, 1051–1059
https://www.ncbi.nlm.nih.gov/pubmed/27816657

Li, G., Yu, K., Li, F., Xu, K., Li, J., He, S., ... Tan, G. (2014, April 28). Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers [Abstract]. Journal of Ethnopharmacology, 153(2), 521–530
https://www.ncbi.nlm.nih.gov/pubmed/24631140

Liang. B., Guo, Z., Xie, F., & Zhai, A. (2013, October 3). Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complementary and Alternative Medicine, 2013(13), 253
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852124/#__ffn_sectitle

Liu, J. H., Li, L., Shang, X. D., Zhang, J. L., & Tan, Q. (2016, May 13). Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus [Abstract]. Journal of Ethnopharmacology, 183, 54–58
https://www.ncbi.nlm.nih.gov/pubmed/26364939

Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009, March). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double‐blind placebo‐controlled clinical trial [Abstract]. Phytotherapy Research, 23(3), 367–372
https://www.ncbi.nlm.nih.gov/pubmed/18844328

Nagano, M., Shimizu, K., Kondo, R., Hayashi, C., Sato, D., Kitagawa, K., & Ohnuki, K. (2010, August). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomedical Research, 31(4), 231–237
https://www.jstage.jst.go.jp/article/biomedres/31/4/31_4_231/_pdf/-char/en

Samberkar, S., Gandhi, S., Naidu, M., Wong, K. H., Raman, J., & Sabaratnam, V. (2015). Lion's mane, Hericium erinaceus and tiger milk, Lignosus rhinocerotis (higher basidiomycetes) medicinal mushrooms stimulate neurite outgrowth in dissociated cells of brain, spinal cord, and retina: An in vitro study [Abstract]. International Journal of Medicinal Mushrooms, 17(11), 1047–1054
https://www.ncbi.nlm.nih.gov/pubmed/26853959

Sheng, X., Yan, J., Meng, Y., Kang, Y., Han, Z., Tai, G., ... Cheng, H. (2017, March 22). Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology [Abstract]. Food & Function, 8(3), 1020–1027
https://www.ncbi.nlm.nih.gov/pubmed/28266682

Wang, M., Konishi, T., Gao, Y., Xu, D., & Gao, Q. (2015). Anti-gastric ulcer activity of polysaccharide fraction isolated from mycelium culture of lion's mane medicinal mushroom, Hericium erinaceus (higher basidiomycetes) [Abstract]. International Journal of Medicinal Mushrooms, 17(11), 1055–1060
https://www.ncbi.nlm.nih.gov/pubmed/26853960

Wong, K.-H., Naidu, M., David, P., Abdulla, M. A., Abdullah, N., Kuppusamy, U. R., & Sabaratnam, V. (2011, August 11). Peripheral nerve regeneration following crush injury to rat peroneal nerve by aqueous extract of medicinal mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evidence-Based Complementary and Alternative Medicine, 2011
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176599/

Yao, W., Zhang, J. C., Dong, C., Zhuang, C., Hirota, S., Inanaga, K., & Hashimoto, K. (2015, September). Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration [Abstract]. Pharmacology, Biochemistry, and Behavior, 136, 7–12
https://www.ncbi.nlm.nih.gov/pubmed/26150007

Yi, Z., Shao-long, Y., Ai-hong, W., Zhi-chun, S., Ya-fen, Z., Ye-ting, X., & Yu-ling, H. (2015, April 16). Protective effect of ethanol extracts of Hericium erinaceus on alloxan-induced diabetic neuropathic pain in rats. Evidence-based Complementary and Alternative Medicine, 2015
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415746/

Zhang, J., An, S., Hu, W., Teng, M., Wang, X., Qu, Y., ... Wang, D. (2016, November 1). The neuroprotective properties of Hericium erinaceus in glutamate-damaged differentiated PC12 cells and an Alzheimer's disease mouse model. International Journal of Molecular Sciences, 17(11), 1810

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133811/

These statements have not been evaluated by the FDA, this product is not intended to diagnose, cure, or prevent any disease.